Fanny M. Elahi

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

This study investigates the effects of NOTCH3 suppression in human vascular smooth muscle cells, revealing changes in extracellular matrix, cytoskeletal organization, and metabolic pathways.

This study shows that blocking fibrin-induced microglia activation reduces neuronal hyperactivity and restores the neuroimmune interactome in Alzheimer's disease.

This study shows that inhibiting acid sphingomyelinase (ASM) restores RPE function and photoreceptor health in Stargardt disease models by reducing ceramide accumulation and improving EV biogenesis.

This paper uses machine learning to impute missing data in Alzheimer's research, finding that MissForest with Random Forest improves predictions of MTL flexibility.

The paper identifies a proteomic signature linked to vascular dysfunction and neurodegeneration in aging brains, highlighting thromboinflammation as an early pathway to tauopathy.

This study identifies a mechanism by which progranulin deficiency leads to mitochondrial hyperfusion and neuroinflammation in GRN-FTD, showing that targeting C3aR can restore mitochondrial integrity and reduce microglial activation.

The paper identifies plasma proteomic signatures associated with CADASIL stages, revealing fibrosis, angiogenesis, and metabolic alterations.

This study uses proteomic profiling of intracranial atherosclerotic plaques to identify differentially expressed proteins associated with ICAD, revealing potential biomarkers and biological pathways involved in the disease.

This study investigates the association between enlarged perivascular spaces (ePVS) and white matter injury, brain atrophy, cognitive decline, and inflammation markers in CADASIL, finding ePVS correlates with these pathologies and specific plasma proteins.

The paper develops a polygenic risk score integrating AD biomarkers and shows it better predicts cognitive decline than a clinical AD-based PRS.

The paper examines endothelial-derived exosomes in older adults to link endothelial inflammation with white matter injury, cognition, and brain degeneration.

The paper identifies genetic variants associated with Alzheimer's disease and cardiovascular risk factors, showing lipid-related enrichment and pleiotropy beyond APOE.