NeurosciencebioRxivPreprint
A mouse model of hemochromatosis-related mutations with brain iron dyshomeostasis exhibits loss of tyrosine hydroxylase expression in dopaminergic neurons and motor control impairment relevant to Parkinson's disease
Elvis Acquah, Rebecca J. Hood, Chan-An Lin…·Daniel M. Johnstone
This paper describes a mouse model with hemochromatosis-related mutations that exhibit parkinsonian features, including loss of tyrosine hydroxylase and motor impairments, supporting a causal link between iron dysregulation and Parkinson's disease.
1 citation