Elizabeth A. Milward

A mouse model of hemochromatosis-related mutations with brain iron dyshomeostasis exhibits loss of tyrosine hydroxylase expression in dopaminergic neurons and motor control impairment relevant to Parkinson's disease

This paper describes a mouse model with hemochromatosis-related mutations that exhibit parkinsonian features, including loss of tyrosine hydroxylase and motor impairments, supporting a causal link between iron dysregulation and Parkinson's disease.

Crucial role for iron metabolism in mediating influenza A virus infection and associated disease

This study shows that iron metabolism influences influenza A virus infection and disease by altering gene expression, increasing viral titer, and worsening inflammation, with TFR1 inhibition offering protection.