Vegard Vinje

This study shows that sleep deprivation reduces brain clearance rates but preserves their spatial pattern, affecting tau propagation differently in a computational model.

The paper develops a computational model to assess how brain geometry, intracranial pressure, and physiological parameters affect CSF circulation and glymphatic system function during infusion tests in iNPH patients and healthy controls.

The paper quantifies human brain solute transport mechanisms using MRI data and computational modeling, showing that enhanced extracellular diffusion and advection are key during sleep.

The paper models CSF circulation to show that convection in the subarachnoid space rapidly clears tracers from intracranial compartments, reducing clearance time from years to days compared to diffusion.

The paper quantifies uncertainty in tracer distribution in the brain by simulating diffusion and convection models and comparing results to experimental MRI data.