David Murphy

This study examines how testosterone affects gene expression in the paraventricular nucleus of male and female spontaneously hypertensive rats, finding significant changes in gene regulation linked to hormone signaling and blood pressure.

This study examines how dehydration alters brain microtubule electrical activity in the supraoptic nucleus of adult rats, revealing distinct oscillation patterns linked to osmoregulation.

The paper investigates MT electrical oscillations in the hippocampus and neocortex of adult rats, finding region-specific frequency peaks and amplitude differences.

The paper identifies the melanocortin system's role in heightened carotid body chemosensitivity in hypertension, showing MC4R activation influences sympathetic and ventilatory responses.

The paper uses AlphaFold2 to predict structures of three uncharacterized apicoplast proteins and suggests their potential molecular functions as transporters.

The paper uses deep learning to predict structures and functions of hypothetical proteins in Pandoraviruses, identifying some functional roles but finding many remain unclear.

This study uses computational structural biology to reveal the topology and function of Oca2, showing it is a Na+/dicarboxylate symporter with a unique structure and potential role in melanosomal trafficking.

This study investigates the role of Opn3 in the rat hypothalamic SON, showing it regulates neuropeptides involved in water balance, body temperature, and motor activity.

The paper investigates proteome and phosphoproteome dynamics in hypothalamic neurons and identifies differences in response between cell bodies and axonal terminals.

The paper uses structural bioinformatics to predict the structure and function of Tmem41b and its homologues, identifying them as potential transporters with H+ antiporter activity.