Genetic & Genomic MedicineNature CommunicationsPeer-reviewed
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma
Andrew R. Hamel, Wenjun Yan, John M. Rouhana…·Ayellet V. Segrè
Author
Harvard UniversityORCID 0000-0003-2982-9894Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Andrew R. Hamel, Wenjun Yan, John M. Rouhana…·Ayellet V. Segrè
Wenjun Yan, Yi‐Rong Peng, Tavé A. van Zyl…·Joshua R. Sanes
The paper uses scRNA-seq to analyze 85,000 retinal cells from humans, identifies 58 cell types, and compares gene expression between fovea, peripheral retina, and macaques to study blinding diseases.
Yi‐Rong Peng, Karthik Shekhar, Wenjun Yan…·Joshua R. Sanes
The paper classifies and compares cell types in primate fovea and peripheral retina using single-cell RNA-seq, finding conserved and divergent features across species and regions.