Author

Tige R. Rustad

University of WashingtonORCID 0000-0003-2996-2943Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

David R. ShermaniD· 3 shared Shuyi MaiD· 2 shared Amir Banaei‐EsfahaniiD· 1 shared Andrej TrauneriD· 1 shared Ben C. CollinsiD· 1 shared Braden T GriebeliD· 1 shared Christian BeiseliD· 1 shared Edson Petry· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersSystems Biology

David R. ShermanORCID

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3 papers

Recent·Most cited

Systems BiologyNature CommunicationsPeer-reviewedMar 23, 2026

Rv1985c-Driven Transcriptional Network Rewiring Underlies Lineage-Specific Phenotypes in Mycobacterium tuberculosis

Amir Banaei‐Esfahani, Sònia Borrell, Andrej Trauner…·Ben C. Collins

This study identifies lineage-specific transcriptional network rewiring in Mtb by analyzing proteomic and transcriptomic data from L1 and L2 strains, revealing key regulators like Rv1985c that drive phenotypic differences.

2 citationstop 3%

whole-genome sequencingproteomics

𝕏 PostBluesky

Systems BiologyFrontiers in TuberculosisPeer-reviewedApr 2, 2025

Predicting bacterial fitness in Mycobacterium tuberculosis with transcriptional regulatory network-informed interpretable machine learning

Ethan Bustad, Edson Petry, Oliver Gu…·Shuyi Ma

The paper predicts Mtb fitness using a transcription factor activity-based machine learning model trained on RNA-seq data and regulatory network analysis.

5 citations

humanbulk RNA-seq

𝕏 PostBluesky

Systems BiologybioRxivPreprintSep 27, 2018

Network stress test reveals novel drug potentiators in Mycobacterium tuberculosis

Shuyi Ma, Robert Morrison, Samuel J. Hobbs…·David R. Sherman

The paper identifies novel drug potentiators in Mycobacterium tuberculosis using a network-based genetic screening approach to uncover stress response adaptations to isoniazid.

2 citations

bacteria (other)statistical model

𝕏 PostBluesky