Author
Samuel J. Hobbs
Harvard UniversityORCID 0000-0002-4282-8813Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2018-2026 · peak 1/yrCo-Author Collaboration Network
10 top collaborators · 28 mutual co-author links4 papers
Recent·Most cited
A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense
Renee B. Chang, Hunter C. Toyoda, Samuel J. Hobbs, Romi Hadary, Desmond Richmond-Buccola, Tanita Wein, Ilya А. Osterman, Nils Burger, Edward T. Chouchani, Rotem Sorek, Philip J. Kranzusch
The paper identifies Acb4, a viral protein that inhibits bacterial anti-phage defense by sequestering nucleotide signals.
Molecular Cell · Dec 31, 2024Peer-reviewedMicrobiology
Phages overcome bacterial immunity via diverse anti-defense proteins
Erez Yirmiya, Azita Leavitt, Allen Lu, Adelyn E. Ragucci, Carmel Avraham, Ilya А. Osterman, Jeremy Garb, Sadie P. Antine, Sarah E. Mooney, Samuel J. Hobbs, Philip J. Kranzusch, Gil Amitai, Rotem Sorek
This study identifies anti-defense proteins in phages that inhibit bacterial immune systems like Gabija, Thoeris, and Hachiman.
Nature · Nov 22, 2023Peer-reviewedGenetics
Network stress test reveals novel drug potentiators in Mycobacterium tuberculosis
Shuyi Ma, Robert Morrison, Samuel J. Hobbs, Jessica Farrow-Johnson, Tige R. Rustad, David R. Sherman
The paper identifies novel drug potentiators in Mycobacterium tuberculosis using a network-based genetic screening approach to uncover stress response adaptations to isoniazid.
bioRxiv · Sep 27, 2018 · PreprintSystems Biology