Author

Yu-Sung Hsu

Washington University in St. LouisORCID 0000-0003-3040-6805Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Nathan SinghiD· 2 shared Alekhya ParvathaneniiD· 1 shared Alex S. HolehouseiD· 1 shared Andrea L. BredemeyeriD· 1 shared Andrew L. KoenigiD· 1 shared Attila Kovacs· 1 shared Blake Jardin· 1 shared Brandon L. Ason· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Nathan SinghORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 21, 2026

Collateral Immune Cell Signaling Compromises the Efficacy of T-cell Engaging Therapies for Cardiac Fibrosis

Steven Hoseong Yang, Alekhya Parvathaneni, Yun-Ling Pai…·Kory J. Lavine

This study shows that FAP-targeted BiTE(R) molecules, intended to reduce cardiac fibrosis, instead worsen heart function by triggering harmful immune responses.

DOI 10.64898/2026.09.15.751626

mouseexperimental assay

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ImmunologyCancer DiscoveryPeer-reviewedJul 9, 2024

Rational protein engineering to enhance MHC-independent T cell receptors

Ju-Fang Chang, Jack H. Landmann, Tien-Ching Chang…·Nathan Singh

The paper designs MHC-independent T cell receptors (miTCRs) to enhance cancer immunotherapy by improving receptor stability and function through structural modeling and iterative sequence modifications.

10 citations

humanproteomics

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