Christa Buecker

IGNITE infers gene regulatory networks from scRNA-seq data and accurately simulates gene perturbations with 74% accuracy in murine pluripotent stem cells.

This study uses 3D in vitro models to investigate centriole and cilium formation in early mouse embryogenesis, showing their dispensability in some models and importance in others.

The paper shows that enhancer cooperativity can compensate for reduced activity over large genomic distances by introducing weak enhancers between strong enhancers and promoters.

The paper shows that differences in cell cycle phase do not explain the asynchronous exit from naive pluripotency in mouse embryonic stem cells.

The paper shows that Irf1, controlled by the formative pluripotency network, regulates ISG expression and Oct6 in formative pluripotent cells.

The paper identifies an enhancer element that amplifies Fgf5 expression by accumulating paused RNA Polymerase II, revealing a new mechanism of enhancer collaboration during differentiation.