Graziano Martello

This study identifies a conserved neural stem cell pool driving continuous CNS regeneration in Botryllus schlosseri, showing aging disrupts this process.

IGNITE infers gene regulatory networks from scRNA-seq data and accurately simulates gene perturbations with 74% accuracy in murine pluripotent stem cells.

This study identifies KLF7 as a key inducer of human pluripotency, showing its role in reprogramming somatic cells and enhancing chemical resetting to naive pluripotent stem cells.

This study develops a feeder-free serum-coated system for culturing naive human pluripotent stem cells, maintaining their developmental potential and reducing contamination and mutations.

This study develops a 3D model of human pluripotent epiblast formation and shows that TGF-beta dynamically maintains epithelial identity, independent of canonical pluripotency markers.

This study shows that STAT3 and HIF1α work together to mediate hypoxia responses by physically interacting and enhancing HIF1α transcriptional activity.

The paper shows STAT3 and TFCP2L1 are essential for epiblast self-renewal during diapause, but only TFCP2L1 is needed for deriving embryonic stem cells in vitro.

This study converts conventional human pluripotent stem cells into trophoblast stem cells using a chemical resetting protocol that induces TSC markers and placental imprinted genes.

This study shows that STAT3 phosphorylation variants regulate naïve pluripotency and developmental timing in mouse embryos, with loss of active STAT3 causing developmental delay and metabolic defects.

BrewerIX analyzes allelic expression of imprinted and X-linked genes from bulk and single-cell transcriptomes to identify aberrant expression patterns in various biological contexts.

PsiNorm is a scalable normalization method for scRNA-seq data that performs well in accuracy and computational efficiency compared to other methods.

This paper identifies Y705 and S727 phosphorylation sites on STAT3 as critical for its mitochondrial import and transcriptional activity, which regulate stem cell proliferation in zebrafish and mouse models.

The paper tracks mouse embryonic stem cells during differentiation, finding symmetric divisions and variable lag periods before loss of pluripotency.

This study identifies a common molecular logic governing embryonic stem cell self-renewal and reprogramming through Boolean network analysis and experimental validation.