Seunggyu Lee

This study evaluates the accuracy of stochastic simulations of gene regulation under spatial homogeneity assumptions and finds that spatial heterogeneity must be considered for accurate results, though it increases computational cost.

The paper shows that proteins interact with the endoplasmic reticulum to accumulate near the nucleus without energy expenditure, following Chapmans law instead of Ficks law.

The paper develops a mathematical model showing how spatially coordinated phosphorylation of PER protein ensures precise and robust circadian rhythms despite spatiotemporal noise.