Seok Joo Chae

Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design

This paper develops a mathematical framework to analyze molecular glues, showing that strong ternary complex binding affinity is key for performance, with degrader performance limited by catalytic efficiency and target half-life.

From Homogeneity to Heterogeneity: Refining Stochastic Simulations of Gene Regulation

This study evaluates the accuracy of stochastic simulations of gene regulation under spatial homogeneity assumptions and finds that spatial heterogeneity must be considered for accurate results, though it increases computational cost.

Beyond microtubules: The cellular environment at the endoplasmic reticulum attracts proteins to the nucleus, enabling nuclear transport

The paper shows that proteins interact with the endoplasmic reticulum to accumulate near the nucleus without energy expenditure, following Chapmans law instead of Ficks law.

Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping

The paper develops a mathematical model showing how spatially coordinated phosphorylation of PER protein ensures precise and robust circadian rhythms despite spatiotemporal noise.