Endothelial Cells retain inflammatory memory through chromatin remodeling
Daniel Gonsales Spíndola, Samantha Clark, Amber Bahr, Gabriel Pin de Jesus, Nina Martino, Antony Lowery, Shuhan Lyu, Andrew Seeman, Grace Martino, Giesse Albeche Duarte, Elijah Crosbourne, Peter A. Vincent, Guangchun Bai, Katherine C. MacNamara, Alejandro Pablo Adam, Ramon Bossardi Ramos
This study shows that endothelial cells retain inflammatory memory through chromatin remodeling, with JunB playing a key role in epigenetic priming after sepsis.
bioRxiv · Jun 12, 2025 · PreprintCell Biology