Author

Shuhan Lyu

Albany Medical CollegeORCID 0000-0003-2142-2192Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alejandro Pablo AdamiD· 2 shared Nina MartinoiD· 2 shared Ramon Bossardi RamosiD· 2 shared Abigail E. SalineroiD· 1 shared Amber Bahr· 1 shared Andrew Seeman· 1 shared Antony Lowery· 1 shared Da‐Zhi WangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Alejandro Pablo AdamORCID

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Author profile →

3 papers

Recent·Most cited

PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathy

Yao Wei Lu, Zhuomin Liang, Kerry Dorr, Samantha Ruiz, Xiaoran Huang, Denise Fangnibo Hanvi, Sheri M. Juntilla, Gisela Beutner, Shuhan Lyu, Haipeng Guo, Tiago Fernandes, Ramón A. Espinoza‐Lewis, Tingting Wang, Kathryn S. Li, Xue Li, , Da‐Zhi Wang

This study identifies PCBP1's role in regulating AARS2 alternative splicing and its impact on heart development and congenital cardiomyopathy.

Nature Cardiovascular Research · Apr 20, 2026Peer-reviewedDevelopmental Biology

Endothelial Cells retain inflammatory memory through chromatin remodeling

Daniel Gonsales Spíndola, Samantha Clark, Amber Bahr, Gabriel Pin de Jesus, Nina Martino, Antony Lowery, Shuhan Lyu, Andrew Seeman, Grace Martino, Giesse Albeche Duarte, Elijah Crosbourne, Peter A. Vincent, Guangchun Bai, Katherine C. MacNamara, Alejandro Pablo Adam, Ramon Bossardi Ramos

This study shows that endothelial cells retain inflammatory memory through chromatin remodeling, with JunB playing a key role in epigenetic priming after sepsis.

bioRxiv · Jun 12, 2025 · PreprintCell Biology

A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young mice

Shuhan Lu, Iria Di John Portela, Nina Martino, Ramon Bossardi Ramos, Abigail E. Salinero, Rachel M. Smith, Kristen L. Zuloaga, Alejandro Pablo Adam

bioRxiv · Mar 3, 2024Neuroscience