Author
University College LondonORCID 0000-0003-3204-6356Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Nina Heyer‐Chauhan, Riccardo Ronzoni, Ibrahim Aldobiyan…·David A. Lomas
This study evaluates changes in circulating alpha-1 antitrypsin (AAT) monomers and polymers after liver transplantation in PiZZ AAT deficiency patients.
Panayiota Stylianou, Kish R. Adoni, Mun Peak Nyon…·Bibek Gooptu
This study shows that both terminal misfolding and polymerisation of Z 1-antitrypsin contribute to liver disease phenotypes, with terminal misfolding driving pro-fibrotic responses and metabolic changes.
Elena Plessa, Lien P. Chu, Charity R. Hornby…·Lisa D. Cabrita
The paper investigates the earliest steps of protein misfolding during alpha-1-antitrypsin biosynthesis, revealing co- and post-translational folding pathways and their implications for disease.
Liqiang Zhang, Julie Turk, Henna Monder…·Alexandra R Lucas
This study shows that PEGSerp-1, a virus-derived serpin, improves survival and reduces immunothrombotic damage in a mouse colitis model.