Leen Rigouts

This paper evaluates thin-layer agar (TLA) for faster, accurate bedaquiline-susceptibility testing of Mycobacterium tuberculosis directly from sputum samples, achieving high sensitivity and reducing time to result.

This study analyzes 665 Mycobacterium kansasii complex strains to identify unique and shared genomic signatures, revealing lineage splits, virulence factors, and drug resistance mechanisms.

The paper examines transmission rates of borderline and common rpoB mutations in MDR-TB isolates from Bangladesh, finding no difference in transmission clustering between mutation types.

The paper introduces the GEN-ERA toolbox, a unified bioinformatics workflow for microbial genomics that enables reproducible phylogenetic and metabolic analyses on bacteria and small eukaryotes.

The paper identifies rare alternative resistance markers in M. tuberculosis using gene-wise genome-wide association, uncovering novel associations with second-line injectable drug resistance.

The paper identifies high within-lineage genomic diversity and gene content differences in Mycobacterium tuberculosis complex lineage 5 compared to H37Rv, affecting transmission analysis and suggesting the need for alternative reference genomes.