Sangram Kadam

The paper develops a data-driven non-equilibrium model of chromatin polymer behavior, showing that active forces at specific scales explain anomalous fluctuations and 3D organization.

The paper uses Monte Carlo simulations to study how chromatin compaction and DNA breaks influence gene translocation probabilities.

The paper models X-chromosome inactivation at multiple scales, showing how chromatin reorganization drives Xist expression and silences Tsix through structural changes.

The paper shows that loop extrusion dominates dynamic properties of chromatin, even when intra-chromatin interactions dominate static structure.