Author

Fred W. Keeley

University of TorontoORCID 0000-0003-3319-2793Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1 Organism:multiple species· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Brandon J. PaylissiD· 1 shared Lisa D. MuiznieksiD· 1 shared Sean E. ReichheldiD· 1 shared Simon J. SharpeiD· 1 shared Zi Hao LiuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

Brandon J. PaylissORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintFeb 5, 2026

A free energy landscape screen reveals the disordered conformational ensemble of tropoelastin

Sean E. Reichheld, Lisa D. Muiznieks, Zi Hao Liu…·Simon J. Sharpe

The paper introduces FELS, a method to screen free energy landscapes for disordered proteins, and applies it to tropoelastin, revealing its conformational ensemble and resolving conflicting models.

DOI 10.64898/2026.02.03.703507

humanprotein structure

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BiochemistryMatrix Biology PlusPeer-reviewedSep 27, 2025

Evolutionary Constraints on Positional Sequence, Collective Properties and Sequence Style of Tropoelastin Dictated by Fundamental Requirements for Formation and Function of the Extracellular Elastic Matrix

Fred W. Keeley

This study identifies evolutionary constraints on tropoelastin sequence and structure across Amniotes by analyzing sequence conservation and motifs to understand elastin matrix formation and function.

3 citations

multiple speciesprotein sequence

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