Author

Sean E. Reichheld

Hospital for Sick ChildrenORCID 0000-0002-6979-5695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

Simon J. SharpeiD· 3 shared Asal Nady· 1 shared Brandon J. PaylissiD· 1 shared Fred W. KeeleyiD· 1 shared Lisa D. MuiznieksiD· 1 shared Min JiniD· 1 shared Robert LuiD· 1 shared Zi Hao LiuiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 14 mutual co-author links

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3 shared papersBiochemistry

Simon J. SharpeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Heparin nucleates and promotes tropoelastin coacervation through a transient interaction driven by domain 36

Robert Lu, Sean E. Reichheld, Min Jin, Simon J. Sharpe

This study identifies domain 36 of tropoelastin as the site of transient interaction with heparin, which nucleates and promotes coacervation through multivalent binding.

bioRxiv · May 3, 2026 · PreprintBiochemistry

A free energy landscape screen reveals the disordered conformational ensemble of tropoelastin

Sean E. Reichheld, Lisa D. Muiznieks, Zi Hao Liu, Brandon J. Payliss, Fred W. Keeley, Simon J. Sharpe

The paper introduces FELS, a method to screen free energy landscapes for disordered proteins, and applies it to tropoelastin, revealing its conformational ensemble and resolving conflicting models.

bioRxiv · Feb 5, 2026 · PreprintBiochemistry

An amyloidogenic fragment of the SARS CoV-2 envelope protein promotes serum amyloid A misfolding and fibrillization

Asal Nady, Sean E. Reichheld, Simon J. Sharpe

This study shows that an SARS-CoV-2 envelope peptide promotes serum amyloid A misfolding and fibrillization, contributing to amyloid-related complications in hyper-inflammatory conditions.

bioRxiv · Apr 25, 2024 · PreprintBiochemistry