Katharina F. Heil

The paper outlines the protocol for the EarlyCause project, which investigates the biological mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity using longitudinal data, animal models, and cellular systems.

The paper constructs a configurable synaptic proteome network model to analyze molecular mechanisms of disease co-morbidity by integrating proteomic and interaction data.

The paper maps proteins in biophysical models of synaptic plasticity, finding 4.2% of synaptic proteins are modelled and identifying gaps in disease-related proteins.