Annamaria Cattaneo

Preconceptional social isolation alters inflammatory and transcriptional signalling across the placenta-fetal brain axis

This study shows that prolonged maternal social isolation causes coordinated but distinct molecular changes in placenta and fetal brain, with placental immune and interferon signaling inversely linked to fetal brain cell-cycle processes.

Meta-analysis of CYP2C19 and CYP2D6 metabolic activity on antidepressant response from 13 clinical studies using genotype imputation

This study examines the association between CYP2C19 and CYP2D6 metabolic phenotypes and antidepressant response using genotype imputation across 13 studies, finding no significant associations after correction for multiple testing.

Molecular underpinnings of programming by early-life stress and the protective effects of early dietary ω6/ω3 ratio, basally and in response to LPS: hippocampal mRNA-miRNAs integrated approach

This study investigates how early-life stress and dietary omega-6/omega-3 ratios affect hippocampal mRNA and miRNA expression in adulthood, revealing molecular pathways involved in cognitive function and inflammation.

Faecal microbiota transplantation from Alzheimer's participants induces impairments in neurogenesis and cognitive behaviours in rats

This study transplants gut microbiota from Alzheimer's patients into rats, showing impaired neurogenesis and cognitive behaviors, suggesting a causal link between gut microbiota and Alzheimer's symptoms.

Single molecule long-read real-time amplicon-based sequencing of CYP2D6: a proof-of-concept with hybrid haplotypes

This paper develops a HiFi SMRT amplicon-based method to accurately detect CYP2D6 haplotypes, including fusion genes, with high alignment accuracy.

Cross-validation of technologies for genotyping CYP2D6 and CYP2C19

The paper cross-validates genotyping methods for CYP2D6 and CYP2C19, finding high concordance for CYP2C19 and feasibility of NGS for CYP2D6 with automated interpretation.

Identifying Causative Mechanisms Linking Early-Life Stress to Psycho-Cardio-Metabolic Multi-Morbidity: The EarlyCause Project

The paper outlines the protocol for the EarlyCause project, which investigates the biological mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity using longitudinal data, animal models, and cellular systems.