Paul R. Copeland

The paper uses RNA-seq to compare transcriptome changes in SBP2 and SECISBP2L depleted HepG2 cells, finding distinct gene expression patterns and suggesting SECISBP2L has a noncanonical role in gene regulation.

The paper identifies PTBP1 as an RNA binding protein interacting with the 3' UTR of SELENOP and shows that specific sequences regulate SELENOP mRNA and protein levels in response to selenium concentration.

This study investigates the roles of Sbp2 and Secisbp2l in zebrafish selenoprotein synthesis using CRISPR mutations and 75Se labeling, finding that Secisbp2l is essential for maintaining the full complement of selenoproteins.