Direct mitochondrial import of lactate supports resilient carbohydrate oxidation
Ahmad A. Cluntun, Joseph R. Visker, Jesse N. Velasco‐Silva, James Carrington, Luis Cedeño-Rosario, Giulia C. Napoli, Ji Eon Kim, Thirupura Sundari Shankar, Marisa J. Lang, Rana Hamouche, Álvaro Jesús Narbona‐Pérez, Jing Ling, Ashish Ganeshlalji Toshniwal, Hayden K. Low, Corey Nathaniel Cunningham, , Gregory S. Ducker
This study shows that lactate can be directly imported into mitochondria and oxidized to support cardiac energy production, independent of the pyruvate carrier.
Nature · Oct 28, 2026Peer-reviewedBiochemistry