Cancer BiologyScience AdvancesPeer-reviewed
HnRNP C binding to inverted Alu elements protects the transcriptome from pre-mRNA circularization
Alberto Marini, Consuelo Pitolli, S. Ciccone…·Vittoria Pagliarini
This study identifies hnRNP C as a repressor of circRNA biogenesis in Group 3 medulloblastoma by binding Alu elements and preventing pre-mRNA circularization.
DOI 10.1126/sciadv.aea2351