Author

David P. Horning

Salk Institute for Biological StudiesORCID 0000-0003-3357-6092Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Gerald F. JoyceiD· 2 shared Dmitry LyumkisiD· 1 shared Leonardo Rodrigues de AndradeiD· 1 shared Samantha C NasseriD· 1 shared Timothy S. StrutzenbergiD· 1 shared Wesley G. CochraneiD· 1 shared Xuan Han· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

Gerald F. JoyceORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 20, 2026

Enhanced Fidelity and Sequence Generality of an RNA Polymerase Ribozyme

David P. Horning, Samantha C Nasser, Gerald F. Joyce

This study improves the fidelity and sequence generality of an RNA polymerase ribozyme through 33 rounds of directed evolution.

DOI 10.64898/2026.10.18.759947

experimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintAug 31, 2026

Structure of an RNA polymerase ribozyme replication complex

Timothy S. Strutzenberg, David P. Horning, Wesley G. Cochrane…·Dmitry Lyumkis

The paper presents the structure of an RNA polymerase ribozyme complex bound to RNA substrates, revealing its catalytic mechanism and structural similarity to polymerase proteins.

DOI 10.64898/2026.08.30.748161

structural biologyexperimental assay

𝕏 PostBluesky