Timothy S. Strutzenberg

This study uses cryo-EM to show how filamentation in bovine GDH alters its allosteric response to GTP inhibition, revealing structural mechanisms with implications for disease treatment.

The paper presents the structure of an RNA polymerase ribozyme complex bound to RNA substrates, revealing its catalytic mechanism and structural similarity to polymerase proteins.

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

This study identifies how RORγt mutations affect gene activation by altering chromatin binding modes, explaining context-dependent autoimmunity and host defense outcomes.

The paper resolves conflicting findings on heme's role in REV-ERBβ-NCoR binding by showing heme directly enhances their interaction through structural and biochemical analyses.