Douglas P. Wightman

This study identifies shared genetic factors across eight cardiovascular diseases using large-scale genetic data, revealing clusters and pathways related to vascular biology and systemic risk factors.

This study benchmarks the impact of non-additive genetic effects on polygenic prediction and machine learning approaches using simulated and real data.

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

This study aggregates rare variants in genes associated with brain volume variation in the UK Biobank and finds links to rare brain disorders.

This paper introduces FLAMES, a framework that improves gene prioritization in GWAS loci by integrating SNP-based and convergence-based evidence, outperforming single-modality approaches.

This study identifies shared genetic loci and biological factors across four neurodegenerative diseases: Alzheimer's disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson's disease.

This study identifies 29 genome-wide significant loci and 85 genes associated with cerebellar volume using UK Biobank data, revealing shared genetic links with neurodevelopmental and neurodegenerative disorders.

The paper uses a proxy Alzheimer's disease/dementia phenotype from UK Biobank exomes to identify rare variant-associated genes, finding three replicated genes linked to clinical Alzheimer's.

This study identifies seven novel genetic loci for Alzheimer's disease using a large GWAS and highlights microglia and immune pathways as key contributors to disease pathology.