Rachel M. Brouwer

This study creates a transcriptomic atlas of the human ventral tegmental area, identifies cell types and their functional connectivity, and links them to psychiatric disorders and BMI.

The paper links GWAS-associated genes to single-cell RNA-seq data to identify cell types associated with 14 brain phenotypes, confirming and discovering new cell-type-disease associations.

This paper meta-analyzes longitudinal diffusion MRI studies to show how white matter fractional anisotropy changes with age and identifies genetic influences on these changes.

This study identifies 142 genes associated with both schizophrenia and height, finding enrichment in immune response genes and partial genetic overlap with white blood cell count.

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

This study aggregates rare variants in genes associated with brain volume variation in the UK Biobank and finds links to rare brain disorders.

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

The paper examines age-related variations in cortical thickness across different life stages using gene expression data from a large neuroimaging dataset.

The paper analyzes cortical thickness trajectories in 17,075 individuals to show peak thickness in childhood, steep decline in early adulthood, and slower decline later, with notable exceptions and significant inter-individual variability.

The paper analyzes sex differences in brain structure variability across the lifespan using a large dataset, finding greater male variability in subcortical volumes, cortical surface area, and thickness in most regions.

This study analyzes subcortical volume changes across the lifespan using MRI data from 18,605 individuals, finding age-related declines in some structures and increases in others.

This study reports longitudinal changes in intracranial volume (ICV) from early adulthood to the sixth decade, finding increases until the fourth decade followed by decreases, with cross-sectional results showing larger changes.

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.