Jeanne E. Savage

Sex differences in genetic pathways underlying ischaemic heart disease-depression comorbidity

The paper identifies sex differences in genetic and biological factors contributing to ischaemic heart disease-depression comorbidity, finding higher genetic correlation in females and distinct risk factors by sex.

Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors

This study identifies sex-specific genetic loci and correlations for alcohol use behaviors and their comorbidities using genome-wide association studies.

The genetic landscape of heterogeneity in human functional brain connectivity

The paper identifies genetic variants associated with functional brain connectivity in a large cohort, linking them to neurodevelopment and health-related traits.

Trajectories of genetic risk across dimensions of alcohol use behaviors

This study examines how genetic risk scores for alcohol use behaviors change over time across multiple cohorts, finding varying associations with drinking patterns and trajectories.

Multimodal brain imaging of insomnia, depression and anxiety symptoms: transdiagnostic commonalities and differences

This study uses multimodal brain imaging data from UK Biobank participants to identify shared and distinct brain properties associated with insomnia, depression, and anxiety symptoms.

Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction

The paper uses GWEIS and in silico methods to study gene-environment interactions in alcohol misuse, identifying SES-modulated genes and highlighting challenges in detecting molecular GxE effects.

On the interpretation of transcriptome-wide association studies

This study shows that interpreting TWAS results as evidence of genetic relationships between gene expression and phenotypes leads to inflated type 1 errors and unreliable conclusions.

The genetic overlap between Alzheimer's disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson's disease

This study identifies shared genetic loci and biological factors across four neurodegenerative diseases: Alzheimer's disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson's disease.

Genome-wide association study of cerebellar volume

This study identifies 29 genome-wide significant loci and 85 genes associated with cerebellar volume using UK Biobank data, revealing shared genetic links with neurodevelopmental and neurodegenerative disorders.

Specificity and overlap in the genetic architectures of functional and structural connectivity within cerebral resting-state networks

This study identifies genes associated with structural and functional connectivity in resting-state networks and finds genetic overlap within functional domains.

Uncovering the Genetic Architecture of Broad Antisocial Behavior through a Genome-Wide Association Study Meta-analysis.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.

Rare Variant Aggregation in 148,508 Exomes Identifies Genes Associated with Proxy Alzheimer's disease/Dementia

The paper uses a proxy Alzheimer's disease/dementia phenotype from UK Biobank exomes to identify rare variant-associated genes, finding three replicated genes linked to clinical Alzheimer's.

Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease

This paper conducts a multivariate GWAS of AUDIT items to correct biases and identify novel genetic associations between alcohol consumption, misuse, and health outcomes.

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

This study identifies seven novel genetic loci for Alzheimer's disease using a large GWAS and highlights microglia and immune pathways as key contributors to disease pathology.

Genetic correlates of evolutionary adaptations in cognitive functional brain networks and their relationship to human cognitive functioning and disease

The paper links the rapid evolutionary expansion of cognitive brain networks to gene expression patterns and shows associations with cognitive traits and disorders.

Genetic association study of psychotic experiences in UK Biobank

This study conducts the largest genetic association analysis of psychotic experiences in the UK Biobank, identifying four genome-wide significant loci and showing shared genetic risk with schizophrenia, depression, bipolar disorder, and neurodevelopmental disorders.

GWAS of brain volume on 54,407 individuals and cross-trait analysis with intelligence identifies shared genomic loci and genes

Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

This study identifies 202 genome-wide significant loci for insomnia using a large sample, linking them to specific brain cell types and pathways.

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

This study conducts a large GWAS meta-analysis of neuroticism, identifying 136 novel genetic loci and 599 genes, with functional insights into brain regions and pathways.

Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

The paper identifies brain cell types and genes associated with intelligence using GWAS and single-cell gene expression data from a large cohort.

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

This study identifies 9 novel genetic loci and 215 potential causative genes associated with Alzheimer's disease risk through a large genome-wide association analysis.

Polygenic prediction of the phenome, across ancestry, in emerging adulthood

The paper constructs a polygenic risk atlas for 33 traits in emerging adults and finds genetic risks for schizophrenia, neuroticism, and depression predict various phenotypes.