Dominique de Vienne

The paper models how genetic variation propagates across phenotypic levels using concave relationships to explain phenotypic buffering, dominance, heritability, and inbreeding depression.

The paper integrates protein abundance, metabolic fluxes, and phenotypic traits in yeast to uncover metabolic bases of phenotypic variation.

The paper shows that most heterosis indices do not accurately measure deviation from additivity and recommends using the potence ratio for comparative analyses.

The paper demonstrates that heterosis and inbreeding effects can be decoupled in yeast traits using a half-diallel cross and proteomic data.

This study tests Wright's model of physiological dominance in Arabidopsis thaliana hybrids, finding that non-linear trait relationships explain most heterosis, while genetic distance explains little.

The paper demonstrates that heterosis arises from nonlinear genotype-phenotype relationships through in vitro experiments and computer simulations.