Constantin Blöchl

Direct measurement and reconstruction of intact polyclonal IgG repertoires to preserve molecular and functional connectivity

The paper introduces a method to measure and reconstruct intact IgG repertoires, preserving molecular connectivity between Fab and Fc domains.

Fc proteoforms of ACPA IgG discriminate autoimmune responses in plasma and synovial fluid of rheumatoid arthritis patients and associate with disease activity

The paper identifies Fc proteoforms of ACPA IgG that distinguish autoimmune responses in RA patients and correlate with disease activity.