Hans Ulrich Scherer

This study shows that some anti-topoisomerase 1 autoantibodies (ATAs) in systemic sclerosis (SSc) bind more strongly to TOP1-DNA cleavage complexes, correlating with disease severity and immune activation.

The paper identifies microbial antigen, specifically fungal topoisomerase 1, as a trigger for autoreactive B cells in systemic sclerosis by showing cross-reactivity between human and microbial TOP1.

The paper identifies Fc proteoforms of ACPA IgG that distinguish autoimmune responses in RA patients and correlate with disease activity.

This paper benchmarks six computational methods for reconstructing B-cell receptors from scRNA-seq data, finding BALDR, BASIC, and BRACER perform best overall.