Manfred Wuhrer

CPMsi is a computational pipeline that efficiently processes and integrates large-scale MSI data, enabling faster analysis and discovery of molecular patterns across tissue sections.

The paper characterizes two anti-HPA-1a antibodies from a severe FNAIT case, showing functional differences in platelet activation through FcγRIIa engagement.

This study identifies type 1 LacNAc and LacdiNAc structures on N-glycans as biomarkers of melanoma progression by comparing melanocytes and melanoma cell lines.

The paper replicates ten novel loci associated with human plasma N-glycosylation using MALDI-MS and UHPLC-FD data and identifies potential causal genes.

This study uses patient-derived organoids to analyze glycosylation changes in gastric tissues and shows they mimic in vivo glycosylation profiles and H. pylori interactions.

The paper develops a mass spectrometry-based assay to screen E2/E3 ligase pairs for their ability to form ubiquitin chains and analyze chain types.

The paper identifies Fc proteoforms of ACPA IgG that distinguish autoimmune responses in RA patients and correlate with disease activity.

The paper compares glycosylation patterns of IgA1 and IgA2, finding subclass-specific differences despite similar glycosylation enzyme expression.

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.

This study shows that tumor-expressed nsGSLs impair OT-I T cell activation in vitro and promote tumor growth in vivo by evading immune responses.

This study identifies LRP1 N-glycans with terminal galactoses as ligands for DCIR, revealing its specificity in immune regulation and potential therapeutic applications.

The paper characterizes the non-prime- and prime-side specificity of Pro-Pro endopeptidases using synthetic peptide libraries and mass spectrometry, identifying novel PPEPs and altered specificity in mutants.

This study presents the first large-scale IgA glycomics dataset from twins, identifies shared and specific genetic loci influencing IgA and IgG glycosylation, and shows genetic conservation across ethnicities.

The paper identifies 16 genomic loci associated with IgG galactosylation through GWAS and validates three genes using CRISPR/dCas9 in an in vitro system.

The paper evaluates normalization methods for glycomics data by assessing how well they enable accurate reconstruction of known glycosylation pathway reactions using Gaussian Graphical Models.

The paper describes an e-infrastructure for recording glycomic mass spectrometric data in compliance with MIRAGE reporting guidelines, enabling standardized data submission to a public repository.