The high infectivity of the SARS-CoV-2 Omicron variant is associated with an exclusive S477N spike receptor-binding domain mutation
Jadson C. Santos, Elvira Regina Tamarozzi, Mariângela Dametto, Rodrigo Bonacin, Eduardo Antônio Donadi, Geraldo Aleixo Silva Passos
This study uses molecular dynamics simulations to show that the Omicron variant's S477N mutation enhances spike-ACE2 binding, contributing to its higher infectivity compared to Delta.
bioRxiv · Sep 11, 2023 · PreprintBioinformatics