Eduardo Antônio Donadi

The ribonucleoprotein-mediated CRISPR-Cas9 system induces recurrent Aire gene mutations in contrast to the nickase expression vector in murine in vitro or in vivo models

The paper compares CRISPR-Cas9 RNP and nickase systems for inducing Aire gene mutations in murine mTECs, finding recurrent mutations with RNP but not nickase.

The high infectivity of the SARS-CoV-2 Omicron variant is associated with an exclusive S477N spike receptor-binding domain mutation

This study uses molecular dynamics simulations to show that the Omicron variant's S477N mutation enhances spike-ACE2 binding, contributing to its higher infectivity compared to Delta.

Genetic diversity of the LILRB1 and LILRB2 coding regions in an admixed Brazilian population sample

The paper analyzes genetic diversity and selection patterns in LILRB1 and LILRB2 genes in a Brazilian population, identifying SNVs, haplotypes, and evidence of positive and purifying selection.

KIR2DL4 genetic diversity in a Brazilian population sample: implications for transcription regulation and protein diversity in samples with different ancestry backgrounds

The paper characterizes KIR2DL4 genetic diversity in a Brazilian population, identifies new sequences, and shows ancestry influences allele frequencies.