Author

Pierce J. Ogden

Harvard UniversityORCID 0000-0003-3444-6214Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

George McDonald ChurchiD· 2 shared Gleb KuznetsoviD· 1 shared Nicholas J. ConwayiD· 1 shared Nina K. JainiD· 1 shared Ryan Prescott AdamsiD· 1 shared Surojit BiswasiD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersSynthetic Biology

George McDonald ChurchORCID

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2 papers

Recent·Most cited

Synthetic BiologyeLifePeer-reviewedJun 9, 2023

Comprehensive mutagenesis maps the effect of all single codon mutations in the AAV2 rep gene on AAV production

Nina K. Jain, Pierce J. Ogden, George McDonald Church

The paper systematically evaluates all single codon mutations in the AAV2 rep gene to identify variants that improve AAV2 production, finding that beneficial mutations are synthetic and not naturally occurring.

21 citations

experimental assayvariant effect prediction

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintJun 2, 2018

Toward machine-guided design of proteins

Surojit Biswas, Gleb Kuznetsov, Pierce J. Ogden…·George McDonald Church

This paper explores using supervised learning with DNA synthesis and high-throughput screening to improve protein design, demonstrating generalization to unseen fitness landscape regions.

31 citations

protein sequencemachine learning (classical)

𝕏 PostBluesky