Author

Sphamandla E. Mtambo

University of KwaZulu-NatalORCID 0000-0003-3444-7073Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:mixed model· 1 Approach:statistical model· 1

Frequent Co-Authors

Hezekiel Mathambo KumaloiD· 2 shared Ndumiso M. Buthelezi· 2 shared Anou Moise SomboroiD· 1 shared Ayanda M. MagwenyaneiD· 1 shared Daniel Gyamfi AmoakoiD· 1 shared Elliasu Yakubu SalifuiD· 1 shared Letitia ShunmugamiD· 1 shared Ndumiso Nhlakanipho MhlongoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioinformatics

Hezekiel Mathambo KumaloORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintFeb 19, 2026

Drug Repurposing: A Potential Therapeutic Strategy for the Treatment of Chikugunya Virus

Siphokazi Zondi, Letitia Shunmugam, Sphamandla E. Mtambo…·Hezekiel Mathambo Kumalo

This study identifies Indinavir as a potential inhibitor of CHIKV nsP2 using HIV/HCV protease inhibitors through molecular dynamics simulations.

DOI 10.64898/2026.02.19.706773

statistical modeldrug response / drug discovery

𝕏 PostBluesky

BioinformaticsbioRxivPreprintMar 8, 2022

Molecular Dynamic Investigation of H5N1 Influenza Virus Dual H274Y-I222K Mutation Resistance to Peramivir

Ndumiso M. Buthelezi, Sphamandla E. Mtambo, Daniel Gyamfi Amoako…·Hezekiel Mathambo Kumalo

This study uses molecular dynamics to analyze how mutations in H5N1 influenza virus neuraminidase affect Peramivir binding, finding that mutations reduce binding stability and drug efficacy.

4 citations

𝕏 PostBluesky