Author

Laura E. Spaman

Rensselaer Polytechnic InstituteORCID 0000-0003-3451-9620Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Gaetano Thomas MontelioneiD· 2 shared Theresa A. RamelotiD· 2 shared Yuanpeng Janet HuangiD· 2 shared Ethan H. LiiD· 1 shared James H. PrestegardiD· 1 shared Keith J. FragaiD· 1 shared Michael A. KennedyiD· 1 shared Naohiro KobayashiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 31 mutual co-author links

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2 shared papersBioinformatics

Gaetano Thomas MontelioneORCID

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2 papers

Recent·Most cited

BioinformaticsNature CommunicationsPeer-reviewedApr 27, 2026

Hidden Structural States of Proteins Revealed by Conformer Selection with AlphaFold-NMR

Yuanpeng Janet Huang, Theresa A. Ramelot, Laura E. Spaman…·Gaetano Thomas Montelione

AlphaFold-NMR reveals hidden conformational states of proteins using AI-driven sampling and Bayesian validation, uncovering structural heterogeneity in Gaussia luciferase and Cyclin-Dependent Kinase 2-Associated Protein 1.

6 citationstop 3%

humanprotein structure

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BioinformaticsbioRxivPreprintJan 22, 2023

Blind Assessment of Monomeric AlphaFold2 Protein Structure Models with Experimental NMR Data

Ethan H. Li, Laura E. Spaman, Roberto Tejero…·Gaetano Thomas Montelione

The paper assesses AlphaFold2 models against experimental NMR data for 9 monomeric proteins not used in training, finding they fit the data as well as or better than existing NMR structures.

6 citations

protein structuredeep learning

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