Author

Keith J. Fraga

University of California, DavisORCID 0000-0002-8930-6510Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

Gaetano Thomas MontelioneiD· 2 shared Ian F. KorfiD· 2 shared Theresa A. RamelotiD· 2 shared Yuanpeng Janet HuangiD· 2 shared Arwin Lashawn Anak KendaryiD· 1 shared Dag H. YasuiiD· 1 shared Ethan H. LiiD· 1 shared Ethan Li· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioinformatics

Gaetano Thomas MontelioneORCID

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3 papers

Recent·Most cited

Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression

Osman Sharifi, Viktoria Haghani, Kari E. Neier, Keith J. Fraga, Ian F. Korf, Sophia M. Hakam, Gerald Quon, Nelson Johansen, Dag H. Yasui, Janine M. LaSalle

The paper identifies sex-specific transcriptomic changes in a mouse model of Rett syndrome, showing more differentially expressed genes in females and non-cell-autonomous effects.

Communications Biology · Oct 9, 2024Peer-reviewedGenetics

Blind Assessment of Monomeric AlphaFold2 Protein Structure Models with Experimental NMR Data

Ethan H. Li, Laura E. Spaman, Roberto Tejero, Yuanpeng Janet Huang, Theresa A. Ramelot, Keith J. Fraga, James H. Prestegard, Michael A. Kennedy, Gaetano Thomas Montelione

The paper assesses AlphaFold2 models against experimental NMR data for 9 monomeric proteins not used in training, finding they fit the data as well as or better than existing NMR structures.

bioRxiv · Jan 22, 2023 · PreprintBioinformatics

SpecDB: A Relational Database for Archiving Biomolecular NMR Spectra Data

Keith J. Fraga, Yuanpeng Janet Huang, Theresa A. Ramelot, G.V.T. Swapna, Arwin Lashawn Anak Kendary, Ethan Li, Ian F. Korf, Gaetano Thomas Montelione

The paper introduces SpecDB, a relational database for archiving NMR FID data and metadata, to support machine learning in biomolecular NMR analysis.

Journal of Magnetic Resonance · Jul 16, 2022Peer-reviewedBioinformatics