Author

Luca Miele

Agostino Gemelli University PolyclinicORCID 0000-0003-3464-0068Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Anna AlisiiD· 2 shared Anna Ludovica FracanzaniiD· 2 shared Erika PaoliniiD· 2 shared Giorgio SoardoiD· 2 shared Marica MeroniiD· 2 shared Miriam LongoiD· 2 shared Paola DongiovanniiD· 2 shared A. UrbaniiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Anna AlisiORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintMar 25, 2026

STRmie-HD enables interruption-aware HTT repeat genotyping and somatic mosaicism profiling across sequencing platforms

Alessandro Napoli, Niccolò Liorni, Tommaso Biagini…·Tommaso Mazza

STRmie-HD is a tool for high-resolution genotyping of HTT repeat expansions and somatic mosaicism across sequencing platforms, capturing interruptions and rare variants with high sensitivity.

DOI 10.64898/2026.03.21.713334

humanwhole-genome sequencing

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GeneticsbioRxivPreprintJun 3, 2024

Artificial intelligence as a ploy to delve into the intricate relationship between genetics and mitochondria in MASLD patients

Miriam Longo, Erika Paolini, Marica Meroni…·Paola Dongiovanni

This paper uses AI to develop risk scores for predicting MASLD progression by integrating genetic, anthropometric, and mitochondrial biomarkers.

1 citation

humanbulk RNA-seq

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GeneticsDigestive and Liver DiseasePeer-reviewedFeb 23, 2021

TM6SF2/PNPLA3/MBOAT7 loss-of-function genetic variants impact on NAFLD development and progression both in patients and in in vitro models

M. Longo, M. Meroni, Veronica Erconi…·Paola Dongiovanni

The paper investigates the combined effect of three genetic variants on NAFLD progression in patients and in vitro models, finding increased HCC risk and altered lipid and mitochondrial metabolism.

9 citations

humanbulk RNA-seq

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