Author

Anna Ludovica Fracanzani

University of MilanORCID 0000-0001-5918-0171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Erika PaoliniiD· 3 shared Marica MeroniiD· 3 shared Miriam LongoiD· 3 shared Paola DongiovanniiD· 3 shared Anna AlisiiD· 2 shared Giorgio SoardoiD· 2 shared Luca MieleiD· 2 shared Marco MaggioniiD· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenetics

Erika PaoliniORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintJun 3, 2024

Artificial intelligence as a ploy to delve into the intricate relationship between genetics and mitochondria in MASLD patients

Miriam Longo, Erika Paolini, Marica Meroni…·Paola Dongiovanni

This paper uses AI to develop risk scores for predicting MASLD progression by integrating genetic, anthropometric, and mitochondrial biomarkers.

1 citation

humanbulk RNA-seq

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GeneticsbioRxivPreprintMay 6, 2024

Circulating mitochondrial bioenergetics as fingerprint of the hepatic one: how to monitor genetic MASLD

Erika Paolini, Miriam Longo, Marica Meroni…·Paola Dongiovanni

The paper investigates how genetic variants in PNPLA3, MBOAT7, and TM6SF2 affect mitochondrial function in MASLD, showing that restoring these proteins improves mitochondrial bioenergetics and that circulating respirometry reflects hepatic mitochondrial status.

1 citation

humanbulk RNA-seq

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Genetic & Genomic MedicineHuman Molecular GeneticsPeer-reviewedJul 15, 2022

New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

Frauke C. Degenhardt, David Ellinghaus, Simonas Juzėnas…·Elio Scarpini

This study identifies a new susceptibility locus for severe COVID-19 through a detailed GWAS analysis in European populations, focusing on genetic variants associated with disease severity.

108 citationstop 4%

humanGWAS summary statistics

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GeneticsDigestive and Liver DiseasePeer-reviewedFeb 23, 2021

TM6SF2/PNPLA3/MBOAT7 loss-of-function genetic variants impact on NAFLD development and progression both in patients and in in vitro models

M. Longo, M. Meroni, Veronica Erconi…·Paola Dongiovanni

The paper investigates the combined effect of three genetic variants on NAFLD progression in patients and in vitro models, finding increased HCC risk and altered lipid and mitochondrial metabolism.

9 citations

humanbulk RNA-seq

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