Author

M. Meroni

Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoORCID 0000-0002-4161-4178Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Miriam LongoiD· 4 shared Anna Ludovica FracanzaniiD· 3 shared Erika PaoliniiD· 3 shared Paola DongiovanniiD· 3 shared Anna AlisiiD· 2 shared Giorgio SoardoiD· 2 shared Luca MieleiD· 2 shared Marco MaggioniiD· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersGenetics

Miriam LongoORCID

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4 papers

Recent·Most cited

Artificial intelligence as a ploy to delve into the intricate relationship between genetics and mitochondria in MASLD patients

Miriam Longo, Erika Paolini, Marica Meroni, Michela Ripolone, Laura Napoli, Francesco Gentile, Annalisa Cespiati, Marco Maggioni, Anna Alisi, Luca Miele, Giorgio Soardo, Maurizio Gualtiero Moggio, Anna Ludovica Fracanzani, Paola Dongiovanni

This paper uses AI to develop risk scores for predicting MASLD progression by integrating genetic, anthropometric, and mitochondrial biomarkers.

bioRxiv · Jun 3, 2024 · PreprintGenetics

Circulating mitochondrial bioenergetics as fingerprint of the hepatic one: how to monitor genetic MASLD

Erika Paolini, Miriam Longo, Marica Meroni, Paola Podini, Marco Maggioni, Angelo Quattrini, Anna Ludovica Fracanzani, Paola Dongiovanni

The paper investigates how genetic variants in PNPLA3, MBOAT7, and TM6SF2 affect mitochondrial function in MASLD, showing that restoring these proteins improves mitochondrial bioenergetics and that circulating respirometry reflects hepatic mitochondrial status.

bioRxiv · May 6, 2024 · PreprintGenetics

Cholesterol-associated Locus EHBP1 Protects against NASH Fibrosis

F. Ma, M. Longo, X. Huang, M. Meroni, S. Prakash, E. Paolini, D. Bhattacharya, S. Wang, X. Wang, S. Mughal, S. Hussain, S. Anand, A. Yurdagul, O. Rom, P. Dongiovanni, , B. Cai

This study identifies EHBP1 as a protective locus against NASH fibrosis by regulating cholesterol metabolism and interacting with other cholesterol-related genes.

bioRxiv · Jul 8, 2023 · PreprintPathology

TM6SF2/PNPLA3/MBOAT7 loss-of-function genetic variants impact on NAFLD development and progression both in patients and in in vitro models

M. Longo, M. Meroni, Veronica Erconi, Fabrizia Carli, Chiara Macchi, Francesco Fortunato, Dario Ronchi, Silvia Sabatini, Erika Paolini, Emilia Rita De Caro, Anna Alisi, Luca Miele, Giorgio Soardo, Giacomo Pietro Comi, Luca Valenti, , Paola Dongiovanni

The paper investigates the combined effect of three genetic variants on NAFLD progression in patients and in vitro models, finding increased HCC risk and altered lipid and mitochondrial metabolism.

Digestive and Liver Disease · Feb 23, 2021Peer-reviewedGenetics