M. Longo

This paper uses AI to develop risk scores for predicting MASLD progression by integrating genetic, anthropometric, and mitochondrial biomarkers.

The paper investigates how genetic variants in PNPLA3, MBOAT7, and TM6SF2 affect mitochondrial function in MASLD, showing that restoring these proteins improves mitochondrial bioenergetics and that circulating respirometry reflects hepatic mitochondrial status.

This study identifies EHBP1 as a protective locus against NASH fibrosis by regulating cholesterol metabolism and interacting with other cholesterol-related genes.

The paper investigates the combined effect of three genetic variants on NAFLD progression in patients and in vitro models, finding increased HCC risk and altered lipid and mitochondrial metabolism.