Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing
Aaron Ming Zhi Tan, Cenk Celik, Stella Yue Ting Lee, Mark Veleba, Caroline S. Manzano, Rahim M. K. Abdul, Guillaume Thibault, Kimberly A. Kline
This study identifies E. faecalis extracellular electron transport as a source of ROS that triggers the UPR in epithelial cells, impairing wound healing.
Science Advances · Jan 16, 2026Peer-reviewedMicrobiology