Author

Frances Ding

Harvard UniversityORCID 0000-0003-3494-7692Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:experimental assay· 1 Organism:mouse· 1 Organism:multiple species· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1

Frequent Co-Authors

Carolin RuveniD· 1 shared Jacob SteinhardtiD· 1 shared Janet H. T. SongiD· 1 shared Jeffrey D. MacklisiD· 1 shared Payal Patel· 1 shared Vibhu SahniiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 10 mutual co-author links

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1 shared paperNeuroscience

Carolin RuvenORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintMar 7, 2024

✦ In-depth digest

Protein language models are biased by unequal sequence sampling across the tree of life

Frances Ding, Jacob Steinhardt

Likelihoods from Progen2 and ESM2 protein language models are systematically higher for sequences from some species, tracking evolution-weighted database sequence counts, and pull likelihood-guided designs away from extremophile properties.

57 citations

multiple speciesprotein sequence

𝕏 PostBluesky

NeuroscienceJournal of NeurosciencePeer-reviewedFeb 23, 2023

Cbln1 directs axon targeting by corticospinal neurons specifically toward thoraco-lumbar spinal cord.

Janet H. T. Song, Carolin Ruven, Payal Patel…·Vibhu Sahni

This study identifies Cbln1 as a molecular regulator directing thoraco-lumbar axon extension by corticospinal neurons, showing its sufficiency but not necessity for this targeting.

10 citations

mouseexperimental assay

𝕏 PostBluesky