NeuroscienceNeurobiology of DiseasePeer-reviewed
Reduction of a-synuclein aggregates by PIKfyve inhibition via TFEB-mediated lysosomal biogenesis in a Parkinson disease model
Sara Lucas Del Pozo, Giuseppe Uras, Federico Fierli…·Anthony H.V. Schapira
This study shows that PIKfyve inhibition reduces alpha-synuclein aggregates in a Parkinson's disease model by enhancing lysosomal biogenesis through TFEB activation.
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