Author

Federico Fierli

Aligning Science Across Parkinson'sORCID 0000-0002-8259-2067Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:metagenomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anthony H.V. SchapiraiD· 2 shared Kai‐Yin ChauiD· 2 shared Sofia KoletsiiD· 2 shared Alexandre FamechoniD· 1 shared Amir DehsarviiD· 1 shared Aymeric DavidiD· 1 shared Benoît QuinquisiD· 1 shared Carlos Lazaro-HernandeziD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersNeuroscience

Anthony H.V. SchapiraORCID

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3 papers

Recent·Most cited

Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis

Elisa Menozzi, Mallia Geiger, Victoria Meslier, Federico Fierli, Marine Gilles, Kai‐Yin Chau, Aymeric David, Revi Shahar Golan, Alexandre Famechon, Sofia Koletsi, Christian Morabito, Benoît Quinquis, Nicolas Pons, Stanislav Dusko Ehrlich, Jane Macnaughtan, , Anthony H.V. Schapira

This study investigates whether GBA1 heterozygosity affects gut microbiome composition in a mouse model, finding no significant differences between genotypes.

Frontiers in Neuroscience · Oct 1, 2025Peer-reviewedNeuroscience

Reduction of a-synuclein aggregates by PIKfyve inhibition via TFEB-mediated lysosomal biogenesis in a Parkinson disease model

Sara Lucas Del Pozo, Giuseppe Uras, Federico Fierli, Veronica Lentini, Sofia Koletsi, Carlos Lazaro-Hernandez, Kai‐Yin Chau, Derralynn A. Hughes, Anthony H.V. Schapira

This study shows that PIKfyve inhibition reduces alpha-synuclein aggregates in a Parkinson's disease model by enhancing lysosomal biogenesis through TFEB activation.

Neurobiology of Disease · Aug 12, 2025Peer-reviewedNeuroscience

Alpha-Synuclein co-pathology in Alzheimer's Disease drives tau accumulation

Felix L. Struebing, Xiaoxuan Song, Teodoro De Vecchi, Jeannine Widmann, Federico Fierli, Viktoria Ruf, Qilin Tang, Thomas Arzberger, Sigrun Roeber, Thomas Koeglsperger, Otto Windl, Amir Dehsarvi, Matthias Brendel, Nicolai Franzmeier, Juliane Winkelmann, Jochen Wolfgang Herms

This study shows that alpha-Synuclein co-pathology in Alzheimer's Disease increases tau levels, linking AD and Parkinson's Disease pathogenesis.

bioRxiv · Jan 24, 2025 · PreprintNeuroscience