Molecular BiologybioRxivPreprint
Mitochondrial DNA Release and Activation of the cGAS-STING Pathway in Lethal Stx12 Knockout Mice
Dan-Hua Liu, Fang Li, Run‐Zhou Yang…·Pei-Pei Liu
This study shows that STX12 deficiency leads to mitochondrial dysfunction, mtDNA release, and activation of the cGAS-STING and Type I interferon pathways in mice, contributing to lethal inflammation.