Jian‐Sheng Kang

Optogenetic Control of cAMP Levels and HCN Channels: Implications in Cardiac Physiology and Parkinsons Disease

This study uses optogenetics to control cAMP and HCN channels in cardiac and Parkinson's disease models, showing effects on heart rate and motor function.

Methodologies for Manipulating Cardiomyocyte Physiology: In Vitro and In Vivo Perspectives

This study develops and applies methodologies to manipulate cardiomyocyte physiology in vitro and in vivo, revealing effects of optogenetic and chemogenetic tools on heart rate and calcium dynamics.

Optogenetic Regulation of Mitochondrial Function to Modulate Cell Death

This study uses optogenetic methods to induce cell death by manipulating mitochondrial function through light-sensitive proteins, showing potential for therapeutic applications in diseases with abnormal cell survival.

Mitochondrial DNA Release and Activation of the cGAS-STING Pathway in Lethal Stx12 Knockout Mice

This study shows that STX12 deficiency leads to mitochondrial dysfunction, mtDNA release, and activation of the cGAS-STING and Type I interferon pathways in mice, contributing to lethal inflammation.